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BTEC2230
AU
The University of Newcastle
After examining the biological data provided in Table 1 answer the following questions:
(i) What does the data imply about the optimal linker length?
(ii) Does the biological data indicate that the linker is directly participating in any binding interactions ?
(iii) What does the biological data imply about the bio-active conformation ?
Show what you believe to be the bioactive conformation .
Table 1. CPG 53716 analogues with varying linkers (X).
Note:Indicates the position at which X links to the rest of the molecule.
With regard to the biological data supplied in
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