BTEC2230 Biomolecules

After examining the biological data provided in Table 1 answer the following questions:

(i) What does the data imply about the optimal linker length?

(ii) Does the biological data indicate that the linker is directly participating in any binding interactions ?

(iii) What does the biological data imply about the bio-active conformation ?

Show what you believe to be the bioactive conformation .

Table 1. CPG 53716 analogues with varying linkers (X).

Note:Indicates the position at which X links to the rest of the molecule.

With regard to the biological data supplied in

• Posted on : November 8th, 2019