PHCM 9517 Advanced Biostatistics and Statistical Computing

In this analysis, we are interested in the association between diastolic blood pressure and body frame.

1. Explore the unadjusted association between diastolic blood pressure and body frame using linear regression

a. Regress diastolic blood pressure on the categorical variable: body frame.

b. Interpret the regression coefficients for body frame.

2. Explore the association between diastolic blood pressure and total cholesterol

a. Plot diastolic blood pressure against total cholesterol and describe the relationship.

b. Regress diastolic blood pressure on total cholesterol and interpret the results.

3. Explore the adjusted association between diastolic blood pressure and body frame

a. Fit a multiple linear regression of diastolic blood pressure on body frame and total cholesterol and interpret the results.

b. Does it appear that total cholesterol confounds the association between diastolic blood pressure and body frame? Justify your answer.

c. Fit an appropriate regression model to examine if total cholesterol is an effect modifier of body frame? Justify your answer.

d. Based on your analyses, summarise the relationship between diastolic blood pressure and body frame.

In your answers, you should include an appendix containing the Stata code used. Please include suitable comments so that a reader can follow how the code was used to produce your answers.